MTOR and tuberous sclerosis: The molecular role of mTOR in epileptogenesis has been extensively demonstrated for one of the best-studied mTORpathies, the Tuberos Sclerosis Complex (TSC), in which several mechanisms have been implicated including excitatory/inhibitory synaptic imbalance, leading to hyper-excitability, dysmyelination, impaired autophagy, and induction of immune-proinflammatory pathways [32,36].