ADORA3 and atherosclerosis: A3AR-mediated contraction through the endothelium may play a role in cardiovascular inflammation, including hypertension and atherosclerosis, by affecting the cyclooxygenase signaling pathways [290], and is also linked with reactive oxygen species (ROS) generation via activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase/Nox2 [291].