Furthermore, other in vivo studies have shown that IB-MECA in PC-3 prostate carcinoma cells [322] and CI-IB-MECA in N1S1 rat hepatocellular carcinoma (HCC) cells [323] induced apoptosis and tumor growth inhibition via deregulation of the Wnt and NF-κβ signaling pathways. This evidence concerns the gene NFKB1 and hepatocellular carcinoma.