However, interestingly, there was not a statically significant decrease in tumor burden when CD8+ T cells were depleted during CGX1321 treatment, indicating a partial reliance on CD8+ T cells for tumor recognition, consistent with the above genomic findings of increased T cell functions and supporting the implication of a conversion from a cold TME to one with an improved reliance on T cells for tumor recognition with a decrease in Wnt/β–catenin signaling. This evidence concerns the gene CD8A and neoplasm.