Additionally, DC-specific deletions of the Fzd co-receptor low-density lipoprotein receptor-related protein-5/6 (LRP5/6) in a murine tumor model showed delayed tumor growth with enhanced effector T cell differentiation and decreased Treg differentiation, which was then mimicked pharmacologically via use of the PORCN inhibitor IWP-L6 [29]. Here, LRP5 is linked to neoplasm.