Therefore, on our previous research, we have demonstrated that soluble Wnt decoy receptor of LRP6 (sLRP6E1E2)-expressing Ad (dE1-k35/sLRP6E1E2), which expresses LRP6’ E1 and E2 domains, prevents Wnt-mediated stabilization of cytoplasmic β-catenin, and decreases Wnt/β-catenin signaling, and this construct can degrade extracellular matrix in HDFs, KFs, and primary keloid spheroids, and thus it may be beneficial for the treatment of keloids [6]. The gene discussed is LRP6; the disease is keloid.