We observed that trends of mRNA expression of LELP1, HRNR, CRNN, LOR, SPRR1B and SPRR3 in CTCL were consistent with expression in the control group rather than the AD group, indicating that those CE proteins do not participate in the CTCL skin barrier defect. This evidence concerns the gene SPRR3 and primary cutaneous T-cell non-Hodgkin lymphoma.