Hypercalcemia was observed at early as 3.5 months and persisted up to 21.5 months in age-matched null littermate males (11.31 ± 0.28 mg/dl in Trpc1–/– vs. 9.92 ± 0.41 mg/dl in Trpc1+/+, P < 0.05) (Supplemental Figure 1A; supplemental material available online with this article; https://doi.org/10.1172/jci.insight.132496DS1). This evidence concerns the gene TRPC1 and Hypercalcemia.