With the exception of Casr+/– mice (42) and a newly described mouse model carrying a loss-of-function mutation (D195G) in Gna11 (43), which recapitulates human FHH both at the disease phenotypic and genetic levels, there are no other suitable mouse models for FHH, including orthologous mouse models. Here, CASR is linked to familial hypocalciuric hypercalcemia.