POMC and neoplasm: Excluding the two recurrences, in the six patients with overt EAS, at CS diagnosis, CT identified 4/6 and 68Ga-SSTR-PET/CT 6/6 ACTH-secreting tumours: in two cases 68Ga-SSTR-PET/CT was the first technique able to identify the primary tumour (CT was not conclusive before the nuclear medicine imaging, and confirmed the suspicion only after PET/CT).