CGAS and viral infectious disease: Those three studies have been followed up on by publication of, to name a few, Schoggins’ characterization of the cyclic GMP-AMP synthase gene cGAS as an pan-antiviral factor (12), the identification of a set of “core” ISGs expressed by mammals and chickens (13); and the linking of very rare loss-of-function mutations in IFN system genes to serious outcomes in viral infection (14).