BCHE and Alzheimer disease: In both AD and DLB, there is strong evidence for reduced cholinergic function associated with more frequent VH.24–27 This is consistent with evidence from case series in PD and PDD suggesting improvement in VH with cholinesterase inhibitors28–30 and improvement in VH, among other neuropsychiatric symptoms, in the secondary analysis of a large-scale clinical trial examining the effect of cholinesterase inhibitors on cognition.31