Notably, we found that μMT mice, which lack both regulatory and inflammatory (e.g., GC B cells and plasmablasts) B cells, have equivalent disease severity to WT mice in this model of arthritis, but that chimeric mice, which exclusively lack IL-10-producing B cells, develop exacerbated disease compared to chimeric mice with WT B cells (Carter et al., 2011). Here, IL10 is linked to arthritic joint disease.