Reportedly, an increasing number of prognostic systems, scores and factors are associated with prognosis of patients with RCC, such as TNM stage, Fuhrman nuclear grade, the RENAL score, performance status, C-reactive protein (CRP), Glasgow prognostic score (GPS), neutrophil-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and others (3, 4, 6–9). The gene discussed is CRP; the disease is renal cell carcinoma.