The authors found that hypoxia- stimulated glioma-derived exosomes had a stronger ability to induce MDSCs, and it was the hypoxia-inducible expression of exosomal miR-10a and miR-21 that mediated MDSC differentiation and activation by targeting RAR-related orphan receptor alpha (RORA) and phosphatase and tensin homolog (PTEN) [72]. Here, PTEN is linked to central nervous system cancer.