CXCL1 and cancer: Intriguingly, XIAOPI treatment could remarkably suppress the cancer cell-induced or TAMs-induced HSPCs enrichment throughout the in vivo experiment, and CXCL1 overexpression declined the inhibitory effects of XIAOPI formula on HSPC activation, further implying that TAMs/CXCL1 is a critical signaling accounting for the anti-PMN effects of XIAOPI.