In Table 2, both AFP and CEA showed significantly higher levels among the EpCAM positive cases compared to the EpCAM negative cases (P= 0.022 and 0.024) respectively, while Table 3 shows the comparison of some prognostic factors of HCC according to the positivity of EpCAM expression, which showed significant results with distant metastasis, lymph node metastasis and portal vein thrombosis (PVT). This evidence concerns the gene EPCAM and hepatocellular carcinoma.