The ‘counterattack’ effect can also be observed through the decline of tumor-infiltrating lymphocytes (TILs) in different kind of tumor tissues with FasL overexpression, such as colon (O’Connell et al., 2000), esophageal (Bennett et al., 1998), breast (Ioachim et al., 2005), and oral cancer (Fang et al., 2013). Here, FASLG is linked to neoplasm.