Tumor suppressor p53, “guardian of the genome”, is a sequence-specific transcription factor (Funk et al., 1992; Lane, 1992; Pietenpol et al., 1994) playing a key role in prevention of tumor development by regulating expression of its downstream target genes involved in cell cycle arrest, DNA repair, apoptosis and cell senescence (Vousden and Lu, 2002; Kastenhuber and Lowe, 2017). Here, TP53 is linked to neoplasm.