Somatic mutations in IDH1 and IDH2 occur as early clonal events in AML evolution (Chou et al., 2012; Corces-Zimmerman et al., 2014; Shlush et al., 2014; Molenaar et al., 2015; Papaemmanuil et al., 2016). Here, IDH1 is linked to acute myeloid leukemia.