CASP8 and hepatocellular carcinoma: Studies performed with n-hexane extract of Strobilanthes crispa, showed significant caspase 8 activation in hepatocellular carcinoma cells (Koh et al., 2017); n-hexane extracts of Clinacanthus nutans also showed induction of apoptosis by significant upregulation of caspase 3/7, 8 and 9 in human lung carcinoma and hepatocellular carcinoma cell lines (Ng et al., 2017).