Recent study by Prieto-Granada et al., (2016) showed loss of expression of H3K27me3 in majority of sporadic MPNST cases as compared to NF1-associated MPNST and conclude that H3K27me3 analysis has good sensitivity and robust specificity for the diagnosis of MPNST, particularly without clinical history of NF-1. The gene discussed is NF1; the disease is malignant peripheral nerve sheath tumor.