BCL2 and neoplasm: Over-expression of anti-apoptotic proteins (e.g., Bcl-2, Mcl-1 or Bcl-xL) is observed in many human malignancies including NSCLC, and associated with tumor progression, poor prognosis and chemotherapy resistance (Losert et al., 2007; Akgul, 2009; Othman and Nagoor, 2014; Paul and Jones, 2014).