In Wnt/ß-catenin signaling, nobiletin inhibits its signaling pathway in hypoxia stimulated Caki-1 and 786-O renal cell carcinoma (Liu et al., 2019), and inhibits invasion via inhibition of AKT/GSK3ß/ß-catenin pathway in glioblastoma cells (Zhang et al., 2017). This evidence concerns the gene AKT1 and hereditary clear cell renal cell carcinoma.