These data are in agreement with the other previously published data in the literature reported that higher adiponectin level associated significantly with increased risk of HCC (Chen et al., 2014; Song and Gu, 2015), advanced liver disease (Kaser et al., 2005; Liu et al., 2009) and predicts worse patients’ prognosis (Wang et al., 2014; Siegel et al., 2015;). This evidence concerns the gene ADIPOQ and hepatocellular carcinoma.