Similarly, decreased concentrations of miR-15 and miR-16 assisst Bcl2 expression in the Chronic lymphocytic leukemia (CLL) and activate apoptotic pathway signaling and can be strategizedas an approach for treatment of tumors due to over expression of Bcl2. The miR-145 via dependent TP53 manner has been identified in establishing death induced pro-apoptotic effect. This evidence concerns the gene TP53 and B-cell chronic lymphocytic leukemia.