IFNG and obesity due to melanocortin 4 receptor deficiency: IFN‐gamma is an important activator of innate and adaptive immunity, with immunostimulatory and immunomodulatory effects that enhance the antitumor immune response.40 In addition, Overacre et al. indicated that IFN‐gamma‐induced Treg fragility is required for effective PD1‐targeted immunotherapy.41 Our work suggests that obesity plays a role in immunotherapy through immune‐assisted pathways.