PRKAR1A and Carney complex: In humans, inactivating mutations or deletions of the PRKAR1A gene have been associated with Carney complex (CNC), an autosomal dominant genetic disorder characterized by spotty skin pigmentation and tumors in the endocrine glands, heart (cardiac myxoma), skin, breast, and other body parts (Casey et al., 2000; Kirschner et al., 2000).