However, the mechanisms by which polymorphisms of the glutathione S-transferase can increase the risk of prostate cancer are still unknown (Ntais et al. 2005; Cai et al. 2014; Chirilă et al. 2015; Qadri et al. 2011; Saheb et al. 2016). This evidence concerns the gene HPGDS and Familial prostate cancer.