In univariable analysis, hemoglobin < 7.5 mmol/L, CRP > 10 mg/L, eGFR ≤ 45 mL/min/1.73 m2, and metastatic disease at presentation showed to be significantly correlated with an increased risk of non-closure of the intended temporary stoma (Table 2). Here, CRP is linked to metastatic neoplasm.