Because the AKT2 protein expression and its phosphorylation were both significantly suppressed by siHSDL2, we further conducted rescue experiments to verify the value of AKT2 for the function of HSDL2, which showed that the suppression effect of siHSDL2 on the progression of lung adenocarcinoma cells depended on the AKT2 expression level. Here, AKT2 is linked to lung adenocarcinoma.