The “upstream analysis” tool enables a causal interpretation of the data [38] and confirmed that IL-6, previously reported to play an essential role in MM progression [52], and IL-10, an anti-inflammatory cytokine with important immunoregulatory functions [[53], [54], [55]], can be integrated within a mechanistic network that may account for the previously discussed gene up-regulation. This evidence concerns the gene IL6 and Miyoshi myopathy.