Articular cartilage‐specific mTOR deletions have been shown to be protective against destabilized medial meniscus‐induced osteoarthritis in mice, based on increased autophagy, decreased apoptosis, and decreased catabolic MMP‐13 expression.102 Our anti‐catabolic RNAi findings suggested that the expression and activation of MMPs potentially depend on mTORC1‐mediated mRNA translation and protein synthesis, although the possibility of other regulatory mechanisms including RNA transcription and mRNA stability cannot be excluded. This evidence concerns the gene MTOR and osteoarthritis.