TNF and Low back pain: Studies have indicated that these findings are related to LBP, and a specific correlation has been observed between intervertebral instability and LBP when type I bone marrow changes are observed.16 Furthermore, cells that express the inflammatory cytokine TNF‐α are common in the cartilage endplates of patients with type I and type II changes who present with IVD‐related LBP.17 We believe that these findings are important to help identify painful IVD on MRI.