MYORG and Parkinson disease: Of interest, central pontine calcification was present in over 1/3 of cases, which seems to be a radiologic diagnostic clue for MYORG mutation carriers, as this anatomic region is typically not affected in other genetic PFBC cases.6 As physiologic brain calcifications in this age group are reported in up to 20%,21,22 an association of calcifications, supranuclear gaze palsy, and parkinsonism with atypical features such as ataxia or rapid cognitive decline should prompt physicians to test for MYORG mutations in this subgroup of patients.