ALB and Hepatic failure: Considerations for generalized low plasma proteins (i.e., panhypoproteinemia which is defined as low concentrations of total protein, albumin, and globulins) in context of other abnormalities in blood variables include chronic malnutrition resulting from decreased protein synthesis and/or increased catabolism, in addition to malabsorption and/or maldigestion, and less likely hepatic insufficiency or protein loss from renal disease.