Despite the finding that the highest levels of RAGE expression are in the lung, a plethora of evidence suggests that RAGE plays pathogenic roles in this organ, as RAGE is implicated in such disorders as allergic airway inflammation and asthma, pulmonary fibrosis, lung cancer, chronic obstructive pulmonary disease, acute lunginjury, pneumonia, cystic fibrosis, and bronchopulmonary dysplasia (133). The gene discussed is AGER; the disease is chronic obstructive pulmonary disease.