AGER and obesity due to melanocortin 4 receptor deficiency: In human omental adipose tissue, obesity was associated with increased accumulation of CML-AGE RAGE ligand and RAGE expression compared to lean individuals; interestingly, it was reported that CML-AGE levels were reduced in the circulation of obese subjects, which was proposed to be due to tissue trapping of CML-AGE in the adipose tissue, at least in part on account of higher RAGE expression (107).