In mice devoid of Apoe or Ldlr, and in transgenic mice expressing cytoplasmic domain-deleted RAGE [in endothelial cells (ECs)] or in mice with global genetic deletion of Ager, significant attenuation in atherosclerosis, irrespective of the diabetic state, but particularly in animals with hyperglycemia, was observed (46–48). Here, AGER is linked to Hyperglycemia.