NOX4 and Hepatic fibrosis: Angiotensin II (Ang II), a key player in RAS, induces the generation of NADPH oxidase 4 (NOX4)/mitochondria-derived ROS and aggravates liver fibrosis, while NLRP3 inflammasome activation is tightly connect with NOX4/mitochondria-derived ROS (Cai et al., 2016).