Recent studies have demonstrated that there is an intimate connection between NLRP3 inflammasome and NAFLD, with NAFLD mice showing an evident increased expression of NLRP3, ASC, and caspase-1 in comparison to the mice fed by normal diet (Lv et al., 2019), and a large proportion of mice NAFLD models are caused by high fat diets. This evidence concerns the gene NLRP3 and metabolic dysfunction-associated steatotic liver disease.