HMGB1 was demonstrated to stimulate cell proliferation and migration in a variety of mammalian cells including fibroblasts (Chitanuwat et al., 2013), airway SMCs (Hou et al., 2019), osteosarcoma cells (Guo et al., 2014), and cancer cells (He et al., 2018). The gene discussed is HMGB1; the disease is osteosarcoma.