Evidence of Th1 cells driving pathogenesis-associated mechanisms in autoimmune diseases such as ERU have previously been proven in several studies, revealing increased transcription of IFN-γ in the vitreous as well as higher levels of IFN-γ expression in PBLs from ERU horses (Gilger et al., 1999; Saldinger et al., 2019). The gene discussed is IFNG; the disease is autoimmune disease.