In that study the deletion of exon 9 and 10 in CHEK2 was shown to lead to a premature protein truncation at codon 381 and to evoke a 2-fold increase in the risk of prostate cancer and a 4-fold increase in the risk of familial prostate cancer (Cybulski et al., 2006). This evidence concerns the gene CHEK2 and prostate carcinoma.