In summary, WGS data analysis of three families with reported recurrence of HL allowed us to prioritize 45 coding and 79 non-coding variants from which we subsequently selected and validated one for family I (DICER1), short-listed three in family II (ALAD, CERCAM, and SPTAN1) and two in family III (RAD51 and LPP), to investigate further with validation and functional studies. The gene discussed is CERCAM; the disease is Hodgkins lymphoma.