UCHL1 has variable roles in cancers, depending on histotype: for instance, the expression of UCHL1 correlates with poor prognosis in patients with multiple myeloma (43), mammary carcinoma (44), and pulmonary carcinoma (44), but has tumor suppressive properties in nasopharyngeal (45) and prostatic carcinoma (46). The gene discussed is UCHL1; the disease is AL amyloidosis.