Based on the theory of ceRNA, we found potential ncRNA regulatory pathways involving an oncogene and a tumor suppressor, ENSG00000203739/ENSG00000271646-miR-637-CYBRD1 and TPTEP1-miR-196a-5p-RUFY2, and constructed a local PPI network which might contribute to proliferation and invasion of GBM. This evidence concerns the gene TPTEP1 and glioblastoma.