Interestingly, TRPV4 itself could both promote tumor cell death and metastasis, indicating that TRPVs might play totally different roles in certain scenario, and raising the possibility that certain TRPV, like TRPV4, would benefit both tumor cell invasion and osteoclastogenesis in the context of bone metastasis, which requires further efforts to elucidate. This evidence concerns the gene TRPV4 and neoplasm.