ESR1 and triple-negative breast carcinoma: According to the expression of these three receptors, the breast cancers can be categorized as Luminal A (ER+PR+HER2-), Luminal B (ER+PR+HER2+), HER2+ (ER-PR-HER2+), and triple negative breast cancers (TNBC, ER-PR-HER2-).