Considering the calcium mediated lysosomal functions and the related change of cellular metabolism mediated by organelle contacts are recently one of the most impressive fields in cancer development as well as multiple physiological and pathological functions (114), it would be very interesting to understand the potential promotion of bone metastasis by TRPML1-mediated lysosomal calcium cascades in breast cancer cells and osteoclasts. This evidence concerns the gene MCOLN1 and breast carcinoma.