Till now, though not as much as those reported in breast cancer cells and osteoclasts, multiple calcium channels have also been reported to modulate osteoblast proliferation, differentiation, migration and mineralization, including TRPV1, TRPV4, TRPM7, TRPP2, Cav1.2, ORAI1/SOCE, P2X1, and P2X7. Here, ORAI1 is linked to breast carcinoma.