Considering that TRPC1, TRPC5, and TRPC6, representatives of the different three subsets, all mediate calcium influx and are required for tumor cells proliferation and metastasis in breast cancer cells, the other TRPCs, specifically TRPC3, TRPC4, and TRPC7, might be also important modulators of breast cancer progression in certain scenarios. This evidence concerns the gene TRPC5 and breast cancer.