ERBB2 and breast cancer: In addition, one cannot exclude the possibility that the low expression/activation of TRPs and SOCE in luminal and Her2+ subtypes is the result of a negative feedback, which the over-activation of TRPs and SOCE strongly enhance calcium influx in breast cancers and thus bone metastasis, however, too much calcium burden in turn declines the expression of calcium channels (TRPs, STIM1, and ORA1) to balance the intracellular calcium homeostasis, which has been reported in other cation channels (165).