Both STIM1 deficiency and pharmacological inhibition of SOCE by YM58433 reduce the expression of Vimentin but enhances the expression of E-cadherin stimulated with TGF-β in breast cancer cells, indicating that SOCE is required for maintaining the epithelial conditions in breast cancer cells and thus modulates tumor cell migration. The gene discussed is TGFB1; the disease is breast carcinoma.