In the current study, by rewiring TCGA cervical carcinoma data, including clinical information, HPV status, established molecular clusters, tumor mutation density, and APOBEC3 family gene expression, we demonstrated the correlation between LOXL2 expression status and the molecular characterizations of cervical carcinoma, and found that LOXL2 expression was negatively correlated with the expression of APOBEC3 family genes, especially APOBEC3A, APOBEC3B, APOBEC3D, and APOBEC3G in vitro. The gene discussed is APOBEC3B; the disease is cervical carcinoma.