Moreover, PTEN decreases the levels of pyruvate kinase isozyme M2 (PKM2) and 6- phosphofructo-1-kinase/fructose-2,6-biphosphatase isoform 3 (PFKFB3); and elicits the inhibition of the pro-tumorigenic glutaminase GLS1 thus contributing to the cancer-protection (71). This evidence concerns the gene GLS and cancer.