However, neither in vivo (Figure 3A) nor in vitro (Figure 3B) NLGP treatment shows any effect in VHL expression in tumor tissues or in B16Mel cells, respectively, and suggested that NLGP mediated VEGF downregulation is not associated with VHL-dependent HIF1α degradation (Figures 3A,B). This evidence concerns the gene HIF1A and neoplasm.