CD8A and cancer: We documented that, to combat metastasis, NLGP-mediated immunomodulation [activating CD8+ T cells via influencing maturation of dendritic cells (DCs)] primarily intervenes two hallmarks of cancer, that is, “avoiding immune destruction” and “angiogenesis” (1), which in turn aid to impede “colonization” (2, 7) of disseminated tumor cells at distal organs.