We documented that, to combat metastasis, NLGP-mediated immunomodulation [activating CD8+ T cells via influencing maturation of dendritic cells (DCs)] primarily intervenes two hallmarks of cancer, that is, “avoiding immune destruction” and “angiogenesis” (1), which in turn aid to impede “colonization” (2, 7) of disseminated tumor cells at distal organs. Here, CD8A is linked to neoplasm.