The clinical biochemistry-based indexes, such as prognostic nutritional index (PNI), albumin-to-alkaline phosphatase ratio (AAPR), albumin/globulin ratio (AGR), albumin (ALB), serum urea nitrogen (BUN) and creatinine (CREA) have been considered as independent prognostic factors for many cancers (15–21). This evidence concerns the gene ALB and cancer.