In isoproterenol-induced myocardial infarction rats which fed with oxidized cholesterol-enriched diet TNF-α level in serum and myocardium (653 ± 42, 1375 ± 121) is considerably increased compared to ISO (358 ± 24, P < 0.001and 885 ± 56 P < 0.01) and Chol+ISO group (432 ± 25, P < 0.01 and 1040 ± 94, P < 0.05) (Table 1). This evidence concerns the gene TNF and myocardial infarction.