TLR4 and myocardial infarction: OxLDL may promotes cytokines by TLR-signaling, the PI3K-AKT-pathway, enhance glycolysis, and rise histone H3K4 methylation.27,28 OxLDL could be classified as damage-associated molecular pattern (DAMP).29,30 DAMPs activate of smooth muscle cells and increased production of cytokines in response to restimulation.29 Other studies demonstrated that inhibition of TLR4/MyD88/NFκB signaling pathway could improve the severity of MI and prevent cardiac remodeling.31