F5 and Rare hereditary thrombophilia: The most common inherited thrombophilia is Factor V Leiden (FVL), with prevalence rates of 3%-7%, 5%, 2.2% and 1.2% in general US population,1 Whites, Hispanics and in Blacks respectively.2 However, the prevalence rate of FVL in patients with venous thromboembolism is 50%.1,3 The incidence of venous thromboembolism in patients with FVL is less i.e., 0.5% per annum.4,5