Comparatively, in adenomas, ≥2-fold Notch3 expression was detected in 56% followed by Notch1 (44%), Notch4 (33%), and Notch2 (11%), while for ligand Jag1, mRNA was overexpressed in 33%, Jag2, Dll1, and Dll3 in 11%, whereas Dll4 was not expressed in adenomas. This evidence concerns the gene NOTCH4 and adenoma.