Notch3 and Notch4 expressions were significantly higher in colorectal cancers compared to normal and adenoma tissues (Notch3: normal vs. CRC, p=0.0052, adenoma vs CRC, p=0.0018; Notch4; normal vs. CRC, p=0.0046, adenoma vs. CRC, p=0.036) (Figure 2). This evidence concerns the gene NOTCH4 and colorectal cancer.