MCL1 and cancer: Another mechanism of tumorigenesis driven by mTOR is through the inhibition of 4EBP1 by complex mTORC1, which activates eukaryotic translation initiation factor 4B (eIF4E), leading to the translation of cell cycle regulatory genes and oncogenes (such as antiapoptotic protein MCL-1) in the RNA and promoting the survival of cancer cells in mouse models [35].